Fri Feb 04 2022

40 articles - From Saturday Jan 29 2022 to Friday Feb 04 2022

parm_toc.knit

Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Nephrol Dial Transplant

Kidney injury rates after unilateral nephrectomy in childhood - a systematic review and meta-analysis.

Unilateral nephrectomy during childhood results in signs of kidney injury in > 10% of patients, with no clear difference between the indications for nephrectomy. Therefore, structured follow-up is necessary in al children who underwent nephrectomy, regardless of the indication.

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Studies

RCT, clinical trials, retrospective studies, etc…

Clin J Am Soc Nephrol

Catheter-Associated Bloodstream Infections among Patients on Hemodialysis: Progress before and during the COVID-19 Pandemic.

However, rates of catheter-associated events also decreased between 2018 and 2019, driven by reductions in facilities operated by a large dialysis provider. These data suggest that significant reductions in catheter-associated infections occurred during the pandemic, superimposed on nonpandemic-related reductions in some facilities before the pandemic. Even after the pandemic, it may be prudent to continue some COVID-19 mitigation measures to prevent catheter-associated bloodstream infections.

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Clin Kidney J

Coronary artery calcification progression and long-term cardiovascular outcomes in renal transplant recipients: an analysis by the joint model.

CAC at baseline and coronary calcification progression robustly predict the risk of death and cardiovascular events in renal transplant recipients. These findings support the hypothesis that the link between the calcifying arteriopathy of renal transplant patients and clinical end points in these patients is causal in nature.

Pubmed   Journal   ReadQx   PMC

J Am Soc Nephrol

A Comprehensive Immune Cell Atlas of Cystic Kidney Disease Reveals the Involvement of Adaptive Immune Cells in Injury-Mediated Cyst Progression in Mice.

Collectively, these data highlight the diversity of immune cell involvement in cystic kidney disease.

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Integrin a5 Is Regulated by miR-218-5p in Endothelial Progenitor Cells.

therapeutic cell delivery.

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The Impact of Vaccination on Incidence and Outcomes of SARS-CoV-2 Infection in Patients with Kidney Failure in Scotland.

These data demonstrate a primary vaccine course of two doses has limited impact on COVID-19 infection and its complications in patients treated with KRT. Adjunctive strategies to reduce risk of both COVID-19 infection and its complications in this population are urgently required.

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Kidney Int

Concomitant loss of regulatory T and B cells is a distinguishing immune feature of antibody-mediated rejection in kidney transplantation.

Strikingly, specific cell clusters expressing the transcription factor T-bet were selectively depleted in both TREG and transitional B cell compartments in patients with ABMR. Importantly, the coordinated loss of these T-bet + CXCR5 + TREG and T-bet + CD21 - transitional B cell clusters was correlated with increased and inflammatory donor specific antibody responses, more extensive microvascular inflammation and a higher rate of kidney allograft loss. Thus, our study identified coordinated and persistent defects in regulatory T and B cell responses in patients undergoing ABMR, which may contribute to their loss of humoral immune regulation, and warrant timely therapeutic interventions to replenish and sustain TREG and transitional B cells in these patients.

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Genetic inactivation of Semaphorin 3C protects mice from Acute Kidney Injury.

Employing a beta actin-dependent, inducible knockout of Sema3c, we demonstrate that in acute kidney injury SEMA3C promotes interstitial edema, leucocyte infiltration and tubular injury. Additionally, intravital microscopy combined with Evans Blue dye extravasation and primary culture of magnetically-sorted peritubular endothelial cells identified a novel role for SEMA3C in promoting vascular permeability. Thus, our study points to microvascular permeability as an important driver of injury in acute kidney injury, and to SEMA3C as a novel permeability factor and potential target for therapeutic intervention.

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Histologically resolved small RNA maps in primary focal segmental glomerulosclerosis indicate progressive changes within glomerular and tubulointerstitial regions.

This study marks the first genome scale molecular profiling conducted in histologically characterized glomerular and tubulointerstitial regions. Thus, substantial molecular changes in histologically normal kidney regions in FSGS might contribute to initiating tissue injury or represent compensatory mechanisms. In addition, several small RNAs might contribute to subsequent progression of glomerular and tubulointerstitial injury, and histologically mapping small RNA profiles may be applied to analyze tissue specimens in any disease.

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Nephrol Dial Transplant

Acid-Base Homeostasis: a historical inquiry of its origins and conceptual evolution.

Henderson and Donald D. van Slyke introduced these laboratory-based conceptual advances to the bedside in the 20th century. Clinical studies of acidosis and alkalosis that followed over the past few decades have facilitated and refined the clinical recognition, interpretation and treatment of acid-base disorders.

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Acute kidney injury increases risk of kidney stones- a retrospective propensity score matched cohort study.

In a large cohort of patients, AKI is associated with a greater risk of kidney stones, which increases with higher stages of AKI. This association should be examined in other cohorts and populations for verification.

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Association of diuretic use with increased risk for long-term post-transplantation diabetes mellitus in kidney transplant recipients.

This study demonstrates that diuretics overall are associated with increased risk of developing PTDM in KTRs, independent of established risk factors for PTDM development. The association was present both for thiazide and loop diuretics.

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CONVINCE in the context of existing evidence on haemodiafiltration.

There are indications that the patients receiving the highest convection volumes of HDF result in an improved survival compared with HD. However, the comparative efficacy of HDF vs HD remains unproven. Here we provide a comparative account of the methodology and aims of 'the comparison of high-dose HDF with high-flux HD' (CONVINCE) study in the context of the totality of evidence and how this study will contribute to reaching a higher level of certainty regarding the comparative efficacy of HDF vs HD in people with end-stage kidney disease (ESKD).

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COVID-19 outbreak in vaccinated patients from a hemodialysis unit: antibody titers as a marker of protection from infection.

Anti-spike IgG titer measured prior to exposure correlates to protection from SARS-CoV-2 infection in hemodialysis patients. BNT162b2 vaccination alone or in combination with monoclonal antibodies prevented severe COVID-19.

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Diagnosis and Risk Factors for Intracranial Aneurysms in Autosomal Polycystic Kidney Disease: A cross-sectional study from the Genkyst Cohort.

This study presents epidemiological data reflecting real-life clinical practice. The increased risk for IAs in postmenopausal women suggests a possible protective role of estrogen.

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Heterologous immunization with BNT162b2 followed by mRNA-1273 in dialysis patients: seroconversion and presence of neutralizing antibodies.

Two doses of BNT162b2 followed by one dose of mRNA-1273 within 6 months in patients receiving maintenance dialysis resulted in significant titers of SARS-CoV-2-S-Ab. While two doses of mRNA vaccine only achieved adequate humoral immunity in a minority, the third vaccination boosts the development of virus-neutralizing quantities of SARS-CoV-2 spike antibodies (against wild type SARS-CoV-2) in almost al patients.

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Heterozygous COL4A3/COL4A4 mutations: the hidden part of the iceberg?

Despite the benign course for these patients described in the literature, a significant percentage is at risk for disease progression. Consequently, we suggest that the assessment of these patients must take into account family history, genetic analysis and pathologic findings. After comparison with the literature, our data suggest that a different definition for Alport syndrome must be considered.

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Inflammation and physical dysfunction: responses to moderate intensity exercise in chronic kidney disease.

Systemic inflammation may contribute to reduced physical function in CKD. Twelve weeks of exercise training was unable to reduce the level of chronic systemic inflammation in these patients, but did reduce plasma myostatin concentrations. Further research is required to further investigate this.

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Itching in dialysis patients: impact on health-related quality of life and interactions with sleep problems and psychological symptoms - results from the RENINE/PROMs registry.

The persistence of itching, its impact on HRQOL over time, and the additional effect on HRQOL of sleep problems and psychological symptoms, emphasize the need for recognition and effective treatment of itching to reduce symptom burden and improve HRQOL.

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The 'other' big complication: how chronic kidney disease impacts on cancer risks and outcomes.

Here, we explore the potential mechanisms for the increased risk of cancer observed in CKD, including patient factors (shared risks such as cardiometabolic disease, obesity, smoking, diet, lifestyle and environment), disease (genetic, inflammatory and infective) and treatment factors. In particular, we discuss the ways in which renal adverse events associated with conventional chemotherapies and newer systemic anti-cancer therapies (including targeted and immunotherapies) may contribute to worse cancer outcomes in people with CKD. Finally, we review the potential benefits of acknowledging increased risk of cancer in risk prediction tools used for management of CKD.

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The level of urinary C4d is associated with disease progression in IgA nephropathy with glomerular crescentic lesions: a cohort study.

Urinary C4d/creatinine ratio was a potential useful biomarker that was associated with disease severity and progression in patients with IgAN and crescents.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Kidney Dis

Biomarkers to Predict CKD After Acute Kidney Injury: News or Noise?

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Dialysis Modality Decisions: Choosing Wisely!

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J Am Soc Nephrol

Cisplatin-Induced Kidney Injury: Delivering the Goods.

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Letters&Replies

Letters to the editors and authors’ replies

Clin J Am Soc Nephrol

Renin-Angiotensin-Aldosterone System Inhibitors and the Risk of AKI in COVID-19 Compared with Influenza.

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J Am Soc Nephrol

Arteritis Status and Renal Involvement in ANCA-Associated Vasculitis.

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Authors' Reply.

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Authors' Reply.

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Confirmed Drop in Treatment of Patients with Incident End-Stage Kidney Disease During the Novel Coronavirus Disease 2019 Pandemic.

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Kidney Int

New Onset of Class III Lupus Nephritis with Multi-Organ Involvement after COVID -19 Vaccination.

Pubmed   Journal   ReadQx   PMC


Others

all remaining publications eg case reports, images of the month, etc…

Nat Rev Nephrol

A multidisciplinary approach to cardiorespiratory fitness in CKD.

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A spatial transcriptomic atlas of AKI in female mice.

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ALCAM-CD6 in lupus nephritis.

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An integrated approach towards a public health perspective on chronic kidney disease.

Pubmed   Journal   ReadQx   PMC

Glutamine mitigates antimicrobial resistance.

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Structures of sodium-glucose cotransporters.

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Nephrol Dial Transplant

A new era in cardio-renal risk management: overview of landmark papers published in NDT in 2021.

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Indication for corticosteroids in IgA nephropathy: validation in the European VALIGA cohort of a treatment score based on the Oxford classification.

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Recurrence of glomerulonephritis after kidney transplant.

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Serum creatinine baseline fluctuation and acute kidney injury after intravenous or intra-arterial contrast agent administration - an intraindividual comparison as part of a randomized controlled trial.

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